Regulatory T Cell Immunotherapy in Immune-Mediated Diseases
نویسندگان
چکیده
منابع مشابه
T-cell regulatory mechanisms in specific immunotherapy.
Allergen-specific immunotherapy (SIT) is the only treatment which leads to a lifelong tolerance against previously disease-causing allergens due to restoration of normal immunity against allergens. The description of T-regulatory (Treg) cells being involved in prevention of sensitization to allergens has led to great interest whether they represent a major target for allergen-SIT and whether it...
متن کاملRegulatory Mechanisms in Cell-mediated Immune Responses
Regulatory effects of alloantigen-activated thymus-derived lymphocytes in mixed lymphocyte reactions have been demonstrated. Mice were injected into foot pads with allogeneic spleen cells; 4 days following sensitization spleen or regional lymph node cells from these animals were treated with mitomycin C and incorporated into MLR as regulator populations syngeneic to the responder cell type. Act...
متن کاملRegulatory Mechanisms in Cell-mediated Immune
We have previously described the activation of a population of mixed leukocyte response suppressor T cells (MLR Ts) 1 by H-2-incompatible leukocytes. Reexposure of such cells to priming H-2 alloantigens in vitro triggers the release of a suppressor factor (MLR TsF) that prohibits alloantigen-induced T cell proliferation in the mixed leukocyte response (MLR) (1). Activated MLR Ts and MLR TsF cha...
متن کاملCD4+CD25+ T regulatory cells suppress NK cell-mediated immunotherapy of cancer.
CD4+CD25+ regulatory T cells (Treg) that suppress T cell-mediated immune responses may also regulate other arms of an effective immune response. In particular, in this study we show that Treg directly inhibit NKG2D-mediated NK cell cytotoxicity in vitro and in vivo, effectively suppressing NK cell-mediated tumor rejection. In vitro, Treg were shown to inhibit NKG2D-mediated cytolysis largely by...
متن کاملRegulatory T Cells as Immunotherapy
Regulatory T cells (Tregs) suppress exuberant immune system activation and promote immunologic tolerance. Because Tregs modulate both innate and adaptive immunity, the biomedical community has developed an intense interest in using Tregs for immunotherapy. Conditions that require clinical tolerance to improve outcomes - autoimmune disease, solid organ transplantation, and hematopoietic stem cel...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Stem Cell Reports
سال: 2015
ISSN: 2198-7866
DOI: 10.1007/s40778-015-0025-1